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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HAGH All Species: 30.3
Human Site: Y269 Identified Species: 55.56
UniProt: Q16775 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16775 NP_001035517.1 308 33806 Y269 T L A E E F T Y N P F M R V R
Chimpanzee Pan troglodytes XP_510739 282 31321 Y243 T L A E E F T Y N P F M R V R
Rhesus Macaque Macaca mulatta XP_001090907 308 33886 Y269 T L A E E F T Y N P F M R V R
Dog Lupus familis XP_537013 309 33857 Y270 T I A E E F T Y N P F M R V R
Cat Felis silvestris
Mouse Mus musculus Q99KB8 309 34066 Y270 T L A E E F T Y N P F M R V K
Rat Rattus norvegicus O35952 309 34091 Y270 T L A E E F T Y N P F M R V K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZI23 310 34206 Y271 T I A E E F T Y N P F M R V R
Frog Xenopus laevis NP_001089873 260 29031 K230 P F M R V R E K S V Q E H A G
Zebra Danio Brachydanio rerio Q6P963 303 33787 F264 T V A E E F T F N P F M R V R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_730568 348 38839 W311 T I G E E K S W N P F M R V H
Honey Bee Apis mellifera XP_623458 288 32956 T252 T I Q E E K L T N P F M R V H
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783848 258 28463 G227 Y N P F M R V G A K S I Q D H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O24496 258 28773 R227 L E T N P F M R V D K P E I Q
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 90.2 96.4 86.4 N.A. 87.3 84.7 N.A. N.A. 74.8 68.5 71.4 N.A. 48.5 52.2 N.A. 51.9
Protein Similarity: 100 91.2 98.6 93.5 N.A. 94.8 93.1 N.A. N.A. 86.7 78.5 84 N.A. 64.3 67.8 N.A. 65.5
P-Site Identity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. N.A. 93.3 0 86.6 N.A. 60 60 N.A. 0
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 6.6 100 N.A. 80 66.6 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. 45.4 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 59.7 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 62 0 0 0 0 0 8 0 0 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 8 0 0 0 8 0 % D
% Glu: 0 8 0 77 77 0 8 0 0 0 0 8 8 0 0 % E
% Phe: 0 8 0 8 0 70 0 8 0 0 77 0 0 0 0 % F
% Gly: 0 0 8 0 0 0 0 8 0 0 0 0 0 0 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 24 % H
% Ile: 0 31 0 0 0 0 0 0 0 0 0 8 0 8 0 % I
% Lys: 0 0 0 0 0 16 0 8 0 8 8 0 0 0 16 % K
% Leu: 8 39 0 0 0 0 8 0 0 0 0 0 0 0 0 % L
% Met: 0 0 8 0 8 0 8 0 0 0 0 77 0 0 0 % M
% Asn: 0 8 0 8 0 0 0 0 77 0 0 0 0 0 0 % N
% Pro: 8 0 8 0 8 0 0 0 0 77 0 8 0 0 0 % P
% Gln: 0 0 8 0 0 0 0 0 0 0 8 0 8 0 8 % Q
% Arg: 0 0 0 8 0 16 0 8 0 0 0 0 77 0 47 % R
% Ser: 0 0 0 0 0 0 8 0 8 0 8 0 0 0 0 % S
% Thr: 77 0 8 0 0 0 62 8 0 0 0 0 0 0 0 % T
% Val: 0 8 0 0 8 0 8 0 8 8 0 0 0 77 0 % V
% Trp: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 54 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _